Dr. Malali Gowda

Achievements:

  • Expert on medical and agricultural genomics
  • Established Genomics and Bioinformatics Training (trained over 500 researchers) Program
  • Founded Two Environmental Organizations; DNA Life DNA (2016) and Biodiversity Conservation & Research Trust (2001).
  • Developed Super-Resolution HLA Typing Technology for organ transplantation
  • Developed HLA Allele Calling Software, Tulita.
  • Established the Centre for Functional Genomics and Bioinformatics at Trans-Disciplinary University, Bengaluru.
  • Established the state-of-the-art ‘Next-Generation Genomics Facility’ at C-CAMP/NCBS, Bengaluru.
  • Led the Plant Genome Sequencing program in India: Sequenced Rice, Tulsi, Neem, Sandalwood, Bhodi Tree, etc.
  • Developed several genomic technologies to sequence DNA (HLA-typing, ddRAD, Infectious virus, AFLP, etc) and RNA (Full length mRNA, SAGE, 5’-RATE, CPA-sRNA, RNASeq).
  • Integrated functional genomics into International Rice Genome Sequencing project at Michigan State University, USA.
  • Worked with over 100 research organizations in India for sequencing of humans, animals, plants and microbes.
  • Community based reforestation of barren landscape using local methods. (Website)
  • Has been awarded Environment Stewardship Award 2019 (Awarded by New England Biolabs, USA Passion in Science Awards):In recognition of the community based large scale reforestation carried by DNA Life Organization, India.

Career Opportunities under CFGB:

  1. Functional Genomics (Clinical, Medicinal Plants, Medical , Pharma etc)
  2. Ayurgenomics
  3. Culturomics
  4. Host-Pathogen Interaction
  5. Multiomics
  6. Medical Genomics (Pharmacogenomics)
  7. Big Data Science & Data Science
  8. Genome Biology
  9. HLA & Organ Transplant
  10. Genealogy (Pedigree) Database
  11. Conservation Genomics

Some of my important publications:

  • Mahesh HB, …… M Gowda. Multi-Omics Driven Assembly and Annotation of the Sandalwood (Santalum album) Genome. Plant Physiol. 2018 Apr; 176(4):2772-2788.
  • Shirke MD, Mahesh HB, Gowda M. Genome-wide comparison of Magnaporthe species reveals a host-specific pattern of secretory proteins and transposable elements. PLoS One. 2016; 11:e0162458.
  • Mahesh HB, …… M Gowda. Indica rice genome assembly, annotation and mining of disease resistance genes. BMC Genomics 2016, 17: 242.
  • Gowda M, et al. Comparative analyses of low, medium and high-resolution HLA typing technologies for human populations. Journal of Clinical & Cellular Immunology 2016, 7:2.
  • Rangiaha K, …. M Gowda, UHPLC-MS/SRM method for quantification of neem metabolites from leaf extracts of Meliaceae family plants. Analytical Methods, 2016,8, 2020-2031.
  • Kuravadi KA …… M Gowda. Comprehensive analyses of genomes, transcriptomes and metabolites of neem tree – PeerJ 2015, 3: e1066.
  • Upadhyay AK ……. M Gowda. Genome sequencing of herb Tulsi (Ocimum tenuiflorum) unravels key genes behind its strong medicinal properties. BMC Plant Biology 2015, 15:212.
  • Gowda, M., et al. Genome-wide characterization of methylguanosine-capped and polyadenylated small RNAs in the rice blast fungus Magnaporthe oryzae. Nucleic Acids Research 2010; 38: 7558-69.
  • Gowda, M et al. Robust analysis of 5’-transcript ends (5’-RATE): a high-throughput protocol for characterization of sequence diversity of transcription start sites. Nature Protocols 2007; 2: 1622-32.
  • Gowda, M., et al Magnaporthe oryzae infection triggers RNA variation and antisense transcript expression in rice. Plant Physiology 2007; 144: 524-33.
  • Gowda, M., et al. Robust-LongSAGE (RL-SAGE): a substantially improved LongSAGE method for gene discovery and transcriptome analysis. Plant Physiology 2004; 134: 890-7.

Projects:

  • Medicinal Plants & Ayurgenomics (Bhodi tree, Karkatashringi (Pistacia integerrima), Sita
    Tree (Saraca asoca), Amrutaballi (Tinospora cordiflora), Amla (Embelica officianalis)
  • Food Crop (Rice (Oryza sativa) and Raagi (Eleusine coracana)
  • Microbiome (Human, Bhodi, Neem, Karkatashringi, Malaria, Cow Microbiome)
  • Technology (NGS, Bioinformatics tools, HLA(Human Leukocyte Antigen), Genealogy Database, DNA fingerprinting)
  • Phylogenetic Databases

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