Dr. Malali Gowda

Achievements:

  • Experience on Genomics and Bioinformatics past 20 years
  • Built a state-of-the-art ‘Next-Generation Genomics Facility’ at C-CAMP/NCBS, Bengaluru
  • Established Centre for Functional Genomics & Bio-informatics at TDU, Bengaluru
  • Sequenced the genomes of rice , Tulsi, Neem, Sandalwood etc in India.
  • Developed several genomic technologies to sequence DNA (HLA-typing, ddRAD, Infectious virus, etc) and RNA (Full length mRNA, SAGE, 5’-RATE, CPA-sRNA, RNASeq)
  • Expert in microbiome of plants and humans, Ayurgenomics and Plant genomics
  • Provided genomic services to sequence more than 1000 genomes (prokaryotes and eukaryotes)
  • Community based reforestation of barren landscape using local methods. (Website)

I am interested to engage with PhD students, young people interested in designing and executing innovative educational and outreach programs related to:

  1. Molecular study of plant -pathogen interactions
  2. Study of microbiome of humans and plants
  3. Dissection of traditional medicine using Omic technologies
  4. Development of genomics and bioinformatics tools
  5. Omic database development

Some of my important publications:

  • Mahesh HB, …… M Gowda. Multi-Omics Driven Assembly and Annotation of the Sandalwood (Santalum album) Genome. Plant Physiol. 2018 Apr; 176(4):2772-2788.
  • Shirke MD, Mahesh HB, Gowda M. Genome-wide comparison of Magnaporthe species reveals a host-specific pattern of secretory proteins and transposable elements. PLoS One. 2016; 11:e0162458.
  • Mahesh HB, …… M Gowda. Indica rice genome assembly, annotation and mining of disease resistance genes. BMC Genomics 2016, 17: 242.
  • Gowda M, et al. Comparative analyses of low, medium and high-resolution HLA typing technologies for human populations. Journal of Clinical & Cellular Immunology 2016, 7:2.
  • Rangiaha K, …. M Gowda, UHPLC-MS/SRM method for quantification of neem metabolites from leaf extracts of Meliaceae family plants. Analytical Methods, 2016,8, 2020-2031.
  • Kuravadi KA …… M Gowda. Comprehensive analyses of genomes, transcriptomes and metabolites of neem tree – PeerJ 2015, 3: e1066.
  • Upadhyay AK ……. M Gowda. Genome sequencing of herb Tulsi (Ocimum tenuiflorum) unravels key genes behind its strong medicinal properties. BMC Plant Biology 2015, 15:212.
  • Gowda, M., et al. Genome-wide characterization of methylguanosine-capped and polyadenylated small RNAs in the rice blast fungus Magnaporthe oryzae. Nucleic Acids Research 2010; 38: 7558-69.
  • Gowda, M et al. Robust analysis of 5’-transcript ends (5’-RATE): a high-throughput protocol for characterization of sequence diversity of transcription start sites. Nature Protocols 2007; 2: 1622-32.
  • Gowda, M., et al Magnaporthe oryzae infection triggers RNA variation and antisense transcript expression in rice. Plant Physiology 2007; 144: 524-33.
  • Gowda, M., et al. Robust-LongSAGE (RL-SAGE): a substantially improved LongSAGE method for gene discovery and transcriptome analysis. Plant Physiology 2004; 134: 890-7.

Projects:

  • De novo Sequencing of transcriptome of Karkatashringi (Pistacia integerrima) Galls.
    Funded by Dabur India Pvt Ltd
  • Genetic diversity assessment of Saraca asoca (Roxb.) Willd. population using genotyping by sequencing.
    Funded by Ministry of Environmental Forest (MoEF), Govt. of India.
  • Integrated genomics-assisted breeding for efficient development of superior finger millet varieties for Karnataka.
    Funded By Dept of Agriculture, Govt of Karnataka.
  • Microbiome study of underground parts of Crocus sativus, saffron grown in Kashmir, J&K.
    Funded by DST-SERB
  • A comprehensive microRNA and phosphoproteome analysis of rice in response to neck blast disease.
    Funded by DST-SERB

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